Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity
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چکیده
Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity Hui Xu12, Xiaojing He, Hui Zheng, Lily J Huang, Fajian Hou, Zhiheng Yu, Michael Jason de la Cruz, Brian Borkowski, Xuewu Zhang*, Zhijian J Chen25*, Qiu-Xing Jiang* Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States; CryoEM Shared Resources, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, United States; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States
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Structural basis for the prion-like MAVS filaments in antiviral innate immunity
Mitochondrial antiviral signaling (MAVS) protein is required for innate immune responses against RNA viruses. In virus-infected cells MAVS forms prion-like aggregates to activate antiviral signaling cascades, but the underlying structural mechanism is unknown. Here we report cryo-electron microscopic structures of the helical filaments formed by both the N-terminal caspase activation and recrui...
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